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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Gastroenterology. 2009 Feb 21;136(7):2325–2333. doi: 10.1053/j.gastro.2009.02.051

Figure 5.

Figure 5

SOX9 controls the timing of bile duct development. (A) SOX9-deficient livers showed delayed onset of OPN expression, and (B) persistence of asymmetrical PDS until e18.5 (Ecad/HNF4 and Muc1/AcTub/Lam stainings). (A) After birth, the SOX9-deficient ducts bile ducts were adjacent to the parenchyme, while wild-type embryos were surrounded by periportal mesenchyme. (B) At five weeks of age SOX9-deficient and wild-type mice had normal bile ducts, surrounded by periportal mesenchyme (αSMA/CK stainings). pv, portal vein; *, lumens of developing bile ducts.

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