Table 2.
Odds of coronary heart disease in men who had values of inflammatory factors in top third of distribution of controls relative to those who had values in bottom third of this distribution
| Factor (tertile cut offs) | No of cases
|
No of controls
|
Odds ratio (95% CI) adjusted for:
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Top | Middle | Bottom | Top | Middle | Bottom | Age and town | Age, town, and smoking | Age, town, smoking, and risk factors* | Age, town, smoking, risk factors, socioeconomic status† | |||
| All 506 cases and 1025 controls | ||||||||||||
| C reactive protein (2.4 and 0.9 mg/l) | 268 | 150 | 88 | 347 | 298 | 380 | 3.46 (2.59 to 4.62) | 3.32 (2.47 to 4.47) | 2.92 (2.13 to 4.01) | 2.13 (1.38 to 3.28) | ||
| Serum amyloid A protein (9 and 6 mg/l) | 255 | 144 | 107 | 362 | 351 | 312 | 2.12 (1.60 to 2.80) | 2.13 (1.61 to 2.82) | 1.66 (1.22 to 2.26) | 1.65 (1.07 to 2.55) | ||
| Leucocyte count (7.8 and 6.4×109/l) | 212 | 168 | 110 | 332 | 329 | 330 | 1.89 (1.43 to 2.51) | 1.69 (1.25 to 2.28) | 1.46 (1.06 to 2.00) | 1.12 (0.71 to 1.77) | ||
| Albumin (46 and 44 g/l) | 174 | 141 | 191 | 348 | 347 | 327 | 0.83 (0.63 to 1.10) | 0.90 (0.68 to 1.20) | 0.61 (0.44 to 0.83) | 0.67 (0.43 to 1.04) | ||
| 329 cases and 820 controls without evidence of coronary heart disease at entry | ||||||||||||
| C reactive protein (2.4 and 0.9 mg/l) | 164 | 95 | 70 | 265 | 234 | 321 | 2.93 (2.10 to 4.09) | 2.74 (1.95 to 3.85) | 2.61 (1.81 to 3.77) | 2.31 (1.42 to 3.76) | ||
| Serum amyloid A protein (9 and 6 mg/l) | 163 | 87 | 79 | 284 | 288 | 248 | 1.90 (1.37 to 2.64) | 1.93 (1.38 to 2.68) | 1.50 (1.05 to 2.16) | 1.67 (1.02 to 2.74) | ||
| Leucocyte count (7.8 and 6.4×109/l) | 142 | 104 | 71 | 253 | 261 | 277 | 2.19 (1.56 to 3.07) | 1.87 (1.30 to 2.68) | 1.57 (1.07 to 2.30) | 1.34 (0.80 to 2.27) | ||
| Albumin (46 and 44 g/l) | 115 | 95 | 118 | 282 | 266 | 269 | 0.90 (0.64 to 1.26) | 1.0 (0.71 to 1.41) | 0.65 (0.45 to 0.95) | 0.75 (0.45 to 1.25) | ||
*
Blood pressure, total cholesterol, high density lipoprotein cholesterol, triglycerides, body mass index
†
Occupation, housing tenure, marital status, car ownership, and childhood socioeconomic factors (father's occupation, family car ownership, bathroom in house, hot water tap in house, bedroom sharing, height).
Analyses of acute phase reactants and coronary heart disease were not adjusted for values of other inflammatory markers to avoid possible overadjustment (see results).