Table 3.
GABRG1 SNP allele and genotype frequencies for self-identified EA and AA subjects.
| EA - Connecticut sample | EA - Project Match | AA Subjects | EA c/w AA controls |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP rs# location |
† Allele/ genotype |
Controls (n=535) |
AD (n=372) |
aχ2;p- value |
AD (n=727) |
bχ2; p-value |
Controls (n=100) |
AD (n=148) |
cχ2; p-value |
dχ2; p-value |
| rs2350439-1 | G | .508 | .583 | 9.72; | .555 | 3.37; | .535 | .555 | 0.19 | 0.50 |
| GABRG1-intron 3 | A | .492 | .417 | .002 | .455 | .066 | .465 | .445 | .665 | .479 |
| G/G | .261 | .373 | .297 | .290 | .308 | |||||
| G/A | .494 | .421 | 12.54; | .496 | 3.40; | .490 | .493 | 0.20 | ||
| A/A | .245 | .206 | .002 | .207 | .183 | .220 | .200 | .906 | ||
| rs1497577-2 | T | .544 | .473 | 8.46; | .493 | 6.28; | .636 | .583 | 1.41 | 5.78 |
| GABRG1-intron 2 | A | .456 | .527 | .004 | .507 | .012 | .364 | .417 | .234 | .016 |
| T/T | .305 | .258 | .243 | .424 | .345 | |||||
| T/A | .477 | .430 | 10.03; | .499 | 6.62; | .424 | .476 | 1.56 | ||
| A/A | .218 | .312 | .007 | .257 | .037 | .152 | .179 | .45 | ||
| rs1391166-3 | A | .505 | .563 | 5.40; | .564 | 8.41; | .696 | .728 | 0.52 | 21.3 |
| GABRG1-intron 1 | T | .495 | .437 | .020 | .436 | .004 | .304 | .272 | .470 | <.001 |
| A/A | .254 | .351 | .312 | .512 | .537 | |||||
| A/T | .502 | .425 | 9.24; | .505 | 8.71; | .369 | .381 | .87 | ||
| T/T | .244 | .225 | .010 | .184 | .013 | .119 | .119 | .650 | ||
| rs7654165-4 | C | .534 | .456 | 10.56; | .467 | 11.09; | .321 | .270 | 1.50 | 29.9 |
| GABRG1-1 kb 5′ | T | .466 | .544 | .001 | .533 | .001 | .679 | .730 | .221 | <.001 |
| C/C | .289 | .233 | .209 | .112 | .095 | |||||
| C/T | .490 | .446 | 11.76; | .515 | 11.97; | .418 | .351 | 1.69 | ||
| T/T | .221 | .321 | .003 | .276 | .003 | .469 | .554 | 0.43 | ||
| rs10033451-5 | T | .559 | .479 | 10.89; | .496 | 9.69; | .703 | .639 | 2.17 | 13.9 |
| GABRG1-26 kb 5′ | C | .441 | .521 | .001 | .504 | .002 | .297 | .361 | .140 | <.001 |
| T/T | .323 | .251 | .244 | .521 | .405 | |||||
| T/C | .472 | .457 | 10.68; | .503 | 10.28; | .365 | .466 | 3.22 | ||
| C/C | .205 | .292 | .005 | .253 | .006 | .115 | .128 | .200 | ||
| rs4280776-6 | T | .554 | .490 | 6.86; | .495 | 8.39; | .717 | .652 | 2.22 | 17.0 |
| GABRG1-62 kb 5′ | C | .446 | .510 | .009 | .505 | .004 | .283 | .348 | .136 | <.001 |
| T/T | .317 | .257 | .252 | .522 | .414 | |||||
| GABRA2-63 kb 3′ | T/C | .475 | .464 | 6.71; | .506 | 9.08; | .391 | .476 | 2.65 | |
| C/C | .208 | .278 | .035 | .242 | .011 | .087 | .110 | .266 | ||
†
Allele nucleotide designation refers to the chromosome plus strand sequence.
a
EA Controls compared with EA Connecticut Alcoholics
b
EA Controls compared with EA MATCH Alcoholics
c
AA Controls compared with AA Alcoholics (Connecticut and MATCH samples combined)
d
EA Controls compared with AA Controls