Table 7.

GABRG1-A2 10-SNP extended haplotype (SNPs 3–7 & A-E; rs1391166, 7654165, 10033451, 4280776, 1440133, 567926, 534459, 529826, 279869, 279858) frequencies for self-identified EA and AA subjects.

	EA - Connecticut sample			EA - Project Match		AA Subjects			EA c/w AA controls
Haplotype* g1/a2 risk	Controls (n=535)	AD (n=372)	aχ2; p-value	AD (n=727)	bχ2; p-value	Controls (n=100)	AD (n=148)	cχ2; p-value	dχ2; p-value
−/− TCTT-GAGTGT	.425	.327	14.46; <.001	.366	9.29; .002	.148	.146	0.07; .79	48.52; <.001
+/+ ATCC-AGACTC	.309	.346	3.26; .07	.334	1.69; .19	.135	.165	0.41; .52	17.86; <.001
+/− ATCC-GAGTGT	.109	.141	4.06; .044	.153	8.02; .005	.081	.095	0.41; .52	1.56; .21
−/− ATTT-GAACTT	.003	.000	N/A	.001	N/A	.294	.280	0.09; .76	315.5; <.001
−/− TCTT-GAACTT	.003	.003	N/A	.001	N/A	.114	.073	1.43; .23	103.8; <.001
−/+ TCTT-AGACTC	.055	.052	0.21; .64	.047	0.91; .34	.026	.024	0.08; .78	2.66; .10

^*Only those extended haplotypes with frequency >0.05 in at least one subgroup are shown. Risk haplotype blocks over-represented in alcoholics are indicated by + (ATCC for GABRG1 and AGACTC for GABRA2), all other haplotype blocks are noted with a–sign.

^a2X2 χ² table (haplotype (y) vs. all others) EA Controls compared with EA Connecticut Alcoholics

^bEA Controls compared with EA MATCH Alcoholics

^cAA Controls compared with AA Alcoholics (Connecticut and MATCH combined)

^dEA Controls compared with AA Controls

N/A–χ² table cell expected counts <5