Table 6.

Recommendations based on certainty of evidence, magnitude of net benefit, and contextual issues

Level of Certainty	Recommendation
High or moderate	Recommend for . . .
	. . . if the magnitude of net benefit is Substantial, Moderate, or Smalla, unless additional considerations warrant caution.
	Consider the importance of each relevant contextual factor and its magnitude or finding.
	Recommend against . . .
	. . . if the magnitude of net benefit is Zero or there are net harms.
	Consider the importance of each relevant contextual factor and its magnitude or finding.
Low	Insufficient evidence . . .
	. . . if the evidence for clinical utility or clinical validity is insufficient in quantity or quality to support conclusions or make a recommendation.
	Consider the importance of each contextual factor and its magnitude or finding.
	Determine whether the recommendation should be Insufficient (neutral), Insufficient (encouraging), or Insufficient (discouraging).
	Provide information on key information gaps to drive a research agenda.

^aCategories for the “magnitude of effect” or “magnitude of net benefit” used are Substantial, Moderate, Small, and Zero.⁵⁷