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Rates of severe neutropenia, severe diarrhea, and tumor response by UGT1A1 genotype
| Rates by genotype (%) (95% CI)
|
Risk ratio (95% CI) versus *1/*1 genotype
|
||||
|---|---|---|---|---|---|
| Outcome | *1/*1 | *1/*28 | *28/*28 | *1/*28 | *28/*28 |
| Severe neutropenia15,31–35 | 9.8 (6.8–14) | 18 (14–23) | 38 (22–57) | 1.82 (1.16–2.85) | 3.51 (2.03–6.07) |
| Severe diarrhea31–36 | 18 (11–28) | 27 (20–36) | 27 (12–48) | 1.40 (0.94–2.08) | 1.63 (0.64–4.14) |
| Tumor response31,37 | 41 (33–40) | 45 (33–63) | 70 (40–84) | 1.09 (0.83–1.43) | 1.70 (1.24–2.33) |
