Table 4.

Consensus UGT1A1 allele frequencies stratified by race

	Common allele frequencies (95% confidence interval)		Other allele frequencies (95% confidence interval)
Race	Studies (patients)	*28 (TA7)	*36 (TA5)	*37 (TA8)	*6 (211G>A)	*27 (686C>A)
White	11 (2517)19,20,58–66,72	0.334 (0.309–0.361)	0.003 (0.001–0.008)58,64,65	0.002 (0.001–0.009)58,64	0.005 (0.001–0.03)60	0.00067
Asian/Asian Americana	4 (454)58,64,68,69	0.139 (0.112–0.171)	0.000 (0.00–0.09)58,64	0.000 (0.00–0.09)58,64	0.13b (0.10–0.17)67–69	0.023 (0.014–0.035)67,69
African/African American	3 (411)58,70,71	0.404 (0.358–0.452)58,70,71	0.058 (0.039–0.085)58,70,71	0.043 (0.026–0.070)58,70,71	0.0067	0.0067

^aThe estimates in this table were derived from studies that provided genotype frequency data. Two other studies reported only allele (*28, *36, *37) frequencies in small control groups of healthy Japanese⁶⁶ and African Americans/Jamaicans,⁶⁶,⁸² estimates were consistent.

^bStudies published subsequent to this review reported allele frequencies for the*6 allele among Asian control groups of 0.08 (95% CI 0.06–0.10) and 0.15 (95% CI 0.10–0.21).²⁸,⁷¹