Table 5.

Chemotherapy treatment regimens used in studies selected for analysis

Carlini et al.51 Group 1 (15 patients) received 1000 mg/m2 Capectabine orally twice daily on days 2–15 of 3-wk cycle with 125 mg/m2 of irinotecan (90- min IV infusion) on days 1 and 8 of each cycle. Group 2 (52 patients) received 900 mg/m2 Capectabine orally twice daily for the same period with 100 mg/m2 of irinotecan (90-min IV infusion) on days 1 and 8 of each cycle. Font et al.44 70 mg/m2 of irinotecan (90-min IV infusion) + 25 mg/m2 docetaxel (30-min IV infusion) on days 1, 8, and 15 followed by a 1-wk rest (28-day cycles). Innocenti et al.14 350 mg/m2 of irinotecan (90-min IV infusion) once every 3 wk. Iyer et al.45 300 mg/m2 of irinotecan (90-min IV infusion) once every 3 wk. Marcuello et al.46 Regimen A: 350 mg/m2 of irinotecan (45-min IV infusion) once every 3 wk. Regimen B: Regime A + 3 mg/m2 Tomudex in 15 min IV every cycle. Regimen C: 80 mg/m2 of irinotecan (45-min IV infusion) every wk + 1 dose 2250 mg/m2 5-FU (48 min continuous infusion) every cycle. Regimen D: 180 mg/m2 of irinotecan (45-min IV infusion) every 2 wk + 5-FU and leucovorin. Massacesi et al.47 80 mg/m2 of irinotecan (30-min IV infusion) on days 1, 8, 15, 22, and 36, 43, 50, and 57 days. 3 mg/m2 of raltitrexed 2–4 hr later (15-min IV infusion) on days 1, 22, and 45. Rouits et al.48 IRIFUFOL (28 patients): 85 mg/m2 of irinotecan (90-min IV infusion) + 1200 mg/m2 5-FU (7-hr IV infusion) and 100 mg/m2 bolus L-folinic acid, each wk. FOLFIRI (47 patients): 180 mg/m2 of irinotecan (90-min IV infusion) + 2500 mg/m2 5-FU (continuous infusion) and 400 mg/m2 bolus L-folinic acid, biweekly. Soepenberg et al.49 70 or 80 mg/m2 of irinotecan given orally to fasted patients once daily for 5 days. Toffoli et al.50 Modified FOLFIRI (90% of patients): 180 mg/m2 of irinotecan (2-hr IV infusion) on day 1 + 400 mg/m2 of 5-FU bolus followed by 2,400 mg/m2 of 5-FU (46-hr IV infusion) + 200 mg/m2 of LV on day 1 every 2 wk. FOLFIRI (10% of patients): 180 mg/m2 of irinotecan (2-hr IV infusion) on day 1 + 400 mg/m2 bolus of 5-FU followed by 600 mg/ m2 of 5-FU (22-hr IV infusion) on days 1 and 2 + 200 mg/m2 of LV on days 1 and 2 every 2 wk.