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Multiple alignment of predicted nuclease domains found in the genomic neighborhoods of pAgo genes. A. Predicted nucleases of the Sir2 family. Numbering of the secondary structure elements corresponds that those reported for PDB: 1j8f[51]. B. (D/E)-(D/E)XK family nucleases. The designations are as in Figure 1. Additional coloring is 'o', hydroxyl-group containing residues (ST); '@', aromatic residues (YWF).
