Figure 1.

Remarkable variability at codon 38 of human KCNE1. Extant and baseml-reconstructed tripletts (and the encoded amino acids) were mapped onto the widely accepted phylogeny among catarrhine primates [49] and Eutheria [47,48]. The discontinuous line encircles branches defined as foreground in branch-site analysis (codeml model A). Red indicates non-synonymous nucleotide substitutions and radical amino acid replacements; green highlights synonymous nucleotide substitutions and conservative amino acid exchanges. Only newly arisen tripletts are labelled along the internal branches.