Table 3.
Proportion of children with worse performance on day 7 and day 28 compared to day 0, after treatment with AS7 or MAS7 for P. falciparum, and in the non febrile controls.
| Day 7 - Day 0 | |||||
|
Neurological Test Component |
Result compared to previous test |
AS7 N = 39 |
MAS7 N = 39 |
Controls non febrile N = 35 |
P* 2 × 2a 2 × 2b |
| Box | Worse | 11.6 (5) | 16.3 (7) | 11.4 (4) | 0.757 0.455 |
| Cube | Worse | 14.0 (6) | 16.3 (7) | 31.4 (11) | 1.000 0.186 |
| Ring | Worse | 11.6 (5) | 11.6 (5) | 11.4 (4) | 1.000 0.285 |
| Coin | Worse | 4.7 (2) | 2.3 (1) | 2.9 (1) | 1.000 0.178 |
| Behaviour | Worse | 11.6 (5) | 14.0 (6) | 31.4 (11) | 1.000 < 0.001 |
| Tone | Decreased | 41.9 (18) | 40.5 (17) | 8.8 (3) | 1.000 0.026 |
| Day 28 - Day 0 | |||||
| Box | Worse | 5.1 (2) | 7.7 (3) | 9.7 (3) | 1.000 0.686 |
| Cube | Worse | 15.4 (6) | 20.8 (8) | 16.1 (5) | 0.769 1.000 |
| Ring | Worse | 5.1 (2) | 7.7 (3) | 25.8 (8) | 1.000 0.009 |
| Coin | Worse | 5.1 (2) | 5.1 (2) | 9.7 (3) | 1.000 0.403 |
| Behaviour | Worse | 15.4 (6) | 10.3 (4) | 45.2 (14) | 0.737 0.001 |
| Tone | Decreased | 51.3 (20) | 44.7 (17) | 19.4 (6) | 0.650 0.009 |
*P value comparison of proportions a of 2 × 2 for AS7 vs MAS7, b 2 × 2 tables for malaria treatment pooled vs controls