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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Feb 20;1791(10):975–982. doi: 10.1016/j.bbalip.2009.02.002

Figure 2. Inhibition of PAP-1 blocks the Kdo2-Lipid A stimulated release of AA.

Figure 2

AA release was measured from RAW 264.7 macrophages preincubated with and without (A) 1 μM pyrrophenone, (B) 25 μM BEL, or (C) 50 μM propranolol prior to stimulation with (■) and without (□) 100 ng/mL Kdo2-Lipid A. The media was collected at 1 hour following Kdo2-Lipid A stimulation and analyzed for AA release by HPLC-MS. A representative experiment of three individual experiments is shown. Data are expressed as mean values ± S.D. of three individual replicates.