. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: Neuropsychopharmacology. 2009 Jun 24;34(11):2442–2449. doi: 10.1038/npp.2009.65

Table 3.

Genotype and allele frequencies of NK1R SNPs for alcohol-dependent and control subjects

db SNP ID	Frequencies from HapMap-CEU data set		Genotype count (frequency) from the present study							Allele count (frequency)
	Genotype	Allele		AD			Controls		^P* value	AD		Controls		^P† value
	Genotype	Allele	1/1	1 /2	2/2	1/1	1/2	2 /2	^P* value	1	2	1	2

rs211137
5	GG=0.518
1 = G	GA=0.393	G=0.714	147	102	17	183	126	21	0.0454	396	136	492	168	0.0155
2 = A	AA=0.089	A=0.286	(0.553)	(0.383)	(0.064)	(0.555)	(0.382)	(0.064)	0.0454	(0.744)	(0.256)	(0.745)	(0.255)	0.0155
rs671572
9	^‡GG=0.130
1 = G	GA=0.391	^‡G=0.326	63	129	73	92	164	76	0.0012	255	275	348	316	*0.0006*
2 = A	AA=0.478	A=0.674	(0.238)	(0.487)	(0.275)	(0.277)	(0.494)	(0.229)	0.0012	(0.481)	(0.519)	(0.524)	(0.476)	*0.0006*
rs377186
0	TT=0.491
1 = T	TG=0.404	T=0.693	153	91	18	185	132	16	0.4853	397	127	502	164	0.2544
2 = G	GG=0.105	G=0.307	(0.584)	(0.347)	(0.069)	(0.556)	(0.396)	(0.048)	0.4853	(0.758)	(0.242)	(0.754)	(0.246)	0.2544
rs382131
9	CC=0.186
1 = C	CG=0.475	C=0.424	30	98	137	50	148	136	0.6243	158	372	248	420	0.4708
2 = G	GG=0.339	G=0.576	(0.113)	(0.370)	(0.517)	(0.150)	(0.443)	(0.407)	0.6243	(0.298)	(0.702)	(0.371)	(0.629)	0.4708
rs735668
1 = C	CC=0.281
2 = A	CA=0.474	C=0.518	73	123	68	77	165	93	0.2129	269	259	319	351	0.1393
	AA=0.246	A=0.482	(0.277)	(0.466)	(0.258)	(0.230)	(0.493)	(0.278)	0.2129	(0.509)	(0.491)	(0.476)	(0.524)	0.1393
rs674102
9	GG=0.458
1 = G	GT=0.373	G=0.644	100	112	43	138	154	41	0.3023	312	198	430	236	0.2172
2 = T	TT=0.169	T=0.356	(0.392)	(0.439)	(0.169)	(0.414)	(0.462)	(0.123)		(0.611)	(0.388)	(0.646)	(0.354)	0.2172
rs485310
5	TT=0.167
1 = T	TA=0.333	T=0.333	32	102	128	34	149	148		166	358	217	445	0.0665
2 = A	AA=0.500	A=0.667	(0.122)	(0.389)	(0.489)	(0.103)	(0.450)	(0.447)	0.1212	(0.317)	(0.683)	(0.328)	(0.672)	0.0665
rs443998
7	GG=0.220
1 = G	GA=0.542	G=0.492	58	133	62	69	142	121	0.4375	249	257	280	384	0.3739
2 = A	AA=0.237	A=0.508	(0.229)	(0.526)	(0.245)	(0.208)	(0.428)	(0.364)	0.4375	(0.492)	(0.508)	(0.422)	(0.578)	0.3739
rs727156	TT=0.768
1 = T	TC=0.196	T=0.866	187	67	9	219	96	16	0.7694	441	85	534	128	0.7225
2 = C	CC=0.036	C=0.134	(0.711)	(0.255)	(0.034)	(0.662)	(0.290)	(0.048)	0.7694	(0.838)	(0.162)	(0.807)	(0.193)	0.7225
rs110685
5	GG=0.593
1 = G	AG=0.339	G=0.763	149	90	21	196	117	22	0.8343	388	132	509	161	0.8255
2 = A	AA=0.068	A=0.237	(0.573)	(0.346)	(0.081)	(0.585)	(0.349)	(0.066)	0.8343	(0.746)	(0.254)	(0.760)	(0.240)	0.8255
rs881
1 = G	GG=0.719
2 = C	GC=0.263	G=0.851	184	59	10	221	93	19	0.9394	427	79	535	131	0.7564
	CC=0.018	C=0.149	(0.727)	(0.233)	(0.040)	(0.664)	(0.279)	(0.057)	0.9394	(0.844)	(0.156)	(0.803)	(0.197)	0.7564

HapMap-CEU - Utah residents with ancestry from northern and western Europe, studied in the International HapMap project.

^‡

European American descent, submitted to NCBI dbSNP data base from Perlegen Sciences Inc.

^P*

- Chi-square P value for the statistical model that compared genotypic frequencies of alcoholic and control groups with covariate adjustments.

^P†

- Chi-square P value for the statistical model that compared minor allele frequency in alcoholic group and frequency of the same allele in control group with covariate adjustments.

Statistically significant P values (before correcting for multiple testing) are shown in bold letters, and P values significant after correction for multiple testing are shown in bold italics.