. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: Neuropsychopharmacology. 2009 Jun 24;34(11):2442–2449. doi: 10.1038/npp.2009.65

Table 4.

Association results of major haplotypes formed by SNPs rs6715729, rs735668, and rs6741029 with AD

Haplotype	Hapo-score	P value	Haplotype frequency			Odds ratio
Haplotype	Hapo-score	P value	Pooled	Controls	AD	Lower OR	OR	Upper OR
G-C-G	−2.5405	0.0111	0.2051	0.2346	0.1580	0.4824	0.7641	1.2103
G-A-G	−2.3559	0.0184	0.0737	0.0995	0.0478	0.3415	0.6192	1.1227
A-A-T	−1.5829	0.1134	0.1301	0.1598	0.0921	0.4229	0.7184	1.2203
G-A-T	−1.3526	0.1761	0.1778	0.1826	0.1657	0.5411	0.8205	1.2441
A-C-G	0.2575	0.7968	0.2265	0.2303	0.2222	NA	1.0000	NA
*A-A-G*	*2.8953*	*0.0038*	*0.1267*	*0.0805*	*0.1846*	*1.1552*	*1.8938*	*3.1045*
*G-C-T*	*6.0062*	*1.8992×10⁻⁹*	*0.0486*	*0.0075*	*0.1092*	*3.6194*	*11.3113*	*35.3498*

global-stat = 59.2790; df = 7; p-val = 2.1024 ×10⁻¹⁰

Statistically significant P values (after correcting for multiple testing) for individual haplotype frequency differences in AD and control sample are shown in bold italics.