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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Exp Eye Res. 2009 Jun 12;89(4):538–548. doi: 10.1016/j.exer.2009.05.013

Figure 7.

Figure 7

BDNF released from MSCs can protect RGC-5s from H2O2 mediated cell death. Following treatment with 10 μM H2O2, only 44.5 ± 2.2 % of RGC-5s were present, as compared to vehicle-only treated cultures (A). When H2O2 treated RGC-5s were grown in the presence of BDNF-MSCs or rhBDNF, a significantly greater percentage of cells were present, as compared to RGC-5s grown in the presence of GFP-MSCs (p < 0.001). We have demonstrated less RGC-5s present when grown in the presence of BDNF-MSCs, as compared to vehicle and GFP-exposed cells. Representative images are shown for control RGC-5s (B), RGC-5s exposed to 10 μM H2O2 (C), and RGC-5s exposed to H2O2 and grown in the presence of BDNF-MSCs (D) or GFP-MSCs (E).