Table 2. Sources of variation of neural progenitor cell (nestin-IR) and dividing cells (Ki-67-IR) number in untreated MDD compared to controls and MDD treated with tricyclics (MDD*TCA) or SSRIs (MDD*SSRI) antidepressants.
Nestin-IR cells | MDD vs controls | MDD vs MDD*TCA | MDD vs MDD*SSRI | ||||||
---|---|---|---|---|---|---|---|---|---|
F1,10 | P | η2 | F1,16 | P | η2 | F1,19 | P | η2 | |
Factor | |||||||||
Diagnosis | 27.268 | .014 | .901 | 29.666 | .012 | .908 | 8.411 | .044 | .678 |
Sex | 10.316 | .049 | .775 | 15.007 | .030 | .833 | .243 | .656 | .075 |
Covariates | |||||||||
Age | 1.072 | .377 | .263 | 1.066 | .378 | .262 | 1.820 | .249 | .313 |
PMI | 3.587 | .155 | .545 | 1.947 | .396 | .661 | 26.925 | .121 | .964 |
pH | 2.529 | .210 | .457 | 4.203 | .289 | .808 | 1.880 | .242 | .320 |
Brain Weight | 7.966 | .106 | .799 | 6.121 | .132 | .754 | .585 | .584 | .369 |
Ki-67-IR cells | MDD vs controls | MDD vs MDD*TCA | MDD vs MDD*SSRI | ||||||
F1,10 | P | η2 | F1,10 | P | η2 | F1,10 | P | η2 | |
Factor | |||||||||
Diagnosis | 64.476 | .077 | .985 | 1489.35 | .001 | .999 | 99.201 | .064 | .990 |
Sex | 19.133 | .143 | .950 | .973 | .428 | .327 | 4.774 | .272 | .828 |
Covariates | |||||||||
Age | .044 | .869 | .042 | 8.838 | .207 | .898 | .062 | .827 | .030 |
PMI | 3.105 | .329 | .756 | 3.035 | .332 | .752 | .328 | .625 | .141 |
pH | 4.568 | .279 | .820 | .917 | .514 | .478 | 5.092 | .266 | .836 |
Brain Weight | .090 | .793 | .043 | .066 | .081 | .992 | 3.349 | .318 | .770 |
MDD, major depressive disorder; SSRI, selective serotonin reuptake inhibitor; PMI, post-mortem interval. Numbers in bold represent significant results. Numbers in italic represent results with a trend for significance.