Table 3.

Effect of NXY-059 on infarct volume by brain regional, stroke model, animal species, time from occlusion to treatment onset, length of treatment, loading dose and maintenance dose

Group	Studies	Experiments	Animals	SMD	95% CI	P-value	Heterogeneity P-value
Total volume	15	26	585	−1.17	−1.50 to −0.84	<0.0001	<0.0001
Cortical	5	6	145	−2.17	−2.99 to −1.34	<0.0001	<0.0001
Subcortical	5	6	145	−1.43	−2.00 to −0.86	<0.0001	0.05
Species
Mice	1	1	9	−0.91	−2.31 to 0.49	0.20	–
Rats	12	23	544	−1.05	−1.53 to −0.57	<0.0001	<0.0001
Marmosets	2	2	32	−0.95	−1.70 to −0.21	0.01	0.45
Model
Permanent	8	13	302	−1.05	−1.53 to −0.57	<0.0001	<0.0001
Transient	6	12	259	−1.33	1.84 to −0.82	<0.0001	<0.0001
Thrombotic	1	1	24	−1.08	−2.00 to −0.16	0.02	0.47
Start time (min)
−30	9	18	282	−0.87	−1.36 to −0.38	0.001	<0.0001
>30 to −60	1	1	10	−2.36	−4.29 to −0.43	0.02	–
>60 to −120	1	2	34	−1.21	−2.03 to −0.40	0.003	0.63
>120 to −180	4	9	208	−1.47	−2.04 to −0.89	<0.0001	0.001
240	2	2	30	−2.31	−5.79 to 1.18	0.19	0.02
300	1	1	10	−1.53	−3.27 to 0.19	0.08	–
480	1	1	11	−0.91	−2.30 to 0.48	0.20	–
Treatment length (h)
0†	2	3	39	−2.19	−4.21 to −0.16	0.03	0.006
>0 to −24	10	19	489	−1.08	−1.44 to −0.71	<0.0001	<0.0001
48	3	3	47	−1.13	−1.76 to −0.50	<0.0001	0.50
72	1	1	10	−1.94	−3.51 to −0.38	0.02	–
Loading dose (mg·kg−1)
No load	1	3	77	−0.60	−1.07 to −0.12	0.01	0.66
≤30	9	18	231	−1.69	−2.18 to −1.20	<0.0001	0.004
>30 to ≤60	3	12	154	−0.88	−1.58 to −0.18	0.01	<0.0001
>60 to ≤120	5	5	111	−0.74	−1.44 to −0.04	0.04	0.03
200	1	1	12	−0.77	−2.02 to 0.48	0.23	–
Maintenance dose (mg·kg−1)
No maintenance	2	3	39	−2.19	−4.21 to −0.16	0.03	0.01
≤30	9	20	326	−1.23	−1.63 to −0.82	<0.0001	0.001
>30 to ≤60	4	12	164	−0.94	−1.60 to −0.28	0.01	<0.0001
>60 to ≤120	3	3	44	−1.07	−2.69 to 0.56	0.20	0.01
200	1	1	12	−0.77	−2.02 to 0.48	0.23	–

Data are standardized mean difference (SMD), 95% confidence intervals (95% CI) and significance for effect and heterogeneity. Results in bold are statistically significant.

^†Two studies administered one or two loading doses only, without maintenance.

NXY-059, disodium 2,4-disulphophenyl-N-tert-butylnitrone.