Table 6.
Effect of NXY-059 on motor impairment in rats by model of ischaemia
| Group | Experiments | Animals | Coefficient | 95% CI | P-value |
|---|---|---|---|---|---|
| Rats | 6 | 180 | −0.06 | −0.10 to −0.02 | 0.001 |
| Transient | 4 | 130 | −0.10 | −0.16 to −0.04 | 0.001 |
| Permanent | 1 | 31 | −0.05 | −0.10 to −0.002 | 0.04 |
| Thrombotic | 1 | 19 | −0.02 | −0.14 to 0.09 | 0.67 |
Analyses based on individual animal data only. Data are coefficients per 100 mg·kg−1 of total administered NXY-059 dose with standardization for model and adjustment for time to treatment; 95% confidence intervals (95% CI) and significance. Results in bold are statistically significant.
NXY-059, disodium 2,4-disulphophenyl-N-tert-butylnitrone.