Figure 3.

(A) Vasodilator responses to the K_v7 channel activators flupirtine and retigabine in WT mouse pulmonary arteries and flupirtine in mesenteric arteries pre-constricted with phenylephrine (PE; 10–100 nM). Vehicle (DMSO) data are also shown and illustrate the fall in vascular tone in vessels set up in parallel with those to which K_v7 channel activators were added. (B) Reversal by linopirdine of the flupirtine-induced vasodilator response shown in Figure 3A in the same WT mouse pulmonary and mesenteric arteries. Data are expressed as a percentage of the response to PE-induced preconstruction (A) and as a percentage reversal of flupirtine-induced vasodilation (B) and shown as mean ± SEM from five to eight experiments. DMSO, dimethylsulphoxide; PE, phenylephrine; WT, wild-type mice.