Figure 4.

Vasoconstrictor responses to K⁺ channel blockers in WT and SERT⁺ mouse pulmonary arteries. Concentration response curves to linopirdine, TEA, 4-AP and ZnCl₂ in pulmonary arteries from (A) WT and (B) SERT⁺ mice. Data are expressed as a percentage of the reference vasoconstrictor response to 50 mM KCl and shown as mean ± SEM from five to eight experiments. 4-AP, 4-aminopyridine; SERT⁺, mice that over-express the 5-HT transporter; TEA, tetraethylammonium; WT, wild-type mice; ZnCl₂, zinc chloride.