Athymic nude mice were inoculated s.c. with KOC7C cells or RMG1 cells. When the tumors reached an average size of about 50 mm3, mice were treated with placebo or 2.5 mg/kg RAD001 twice a week for 4 wks. A and C, appearance of subcutaneous tumors.B and D, graphs depicting weekly tumor volumes (mm3) for each treatment group. Points, mean; bars, SD. *, p< 0.05, significantly different from placebo-treated mice. **, p< 0.01, significantly different from placebo-treated mice.