Table 3.
Overview of the diagnostic accuracy of individual tissue criteria as assessed in controlled trials.
| Early myocardial gadolinium enhancement | Validation | Sens | Spec | Acc | PPV | NPV |
|---|---|---|---|---|---|---|
| Friedrich et al., Circulation 1998 (9) | Clinical | 84% | 89% | 86% | 89% | 84% |
| Laissy et al., Chest 2002 (11) | Clinical | 85% | 100% | 89% | 100% | 70% |
| Abdel-Aty et al., J Am Coll Cardiol 2005 (13) | Clinical | 80% | 68% | 74% | 74% | 75% |
| Gutberlet et al., Radiology 2008 (34) | Histology | 63% | 86% | 72% | 86% | 63% |
| Pooled data (n=194) | 74% | 83% | 78% | 86% | 70% | |
| T2 | Validation | Sens | Spec | Acc | PPV | NPV |
| Rieker et al., RoFo 2002 (36) | Clinical | 100% | 50% | 76% | 69% | 100% |
| Laissy et al., Chest 2002 (11) | Clinical | 45% | 100% | 59% | 100% | 39% |
| Abdel-Aty et al., J Am Coll Cardiol 2005 (13) | Clinical | 84% | 74% | 79% | 78% | 81% |
| Gutberlet et al., Radiology 2008 (34) | Histology | 67% | 69% | 67% | 74% | 60% |
| Pooled data (n=178) | 70% | 71% | 70% | 77% | 63% | |
| Late enhancement | Validation | Sens | Spec | Acc | PPV | NPV |
| Rieker et al., RoFo 2002 (36) | Clinical | 45% | 60% | 52% | 56% | 50% |
| Abdel-Aty et al., J Am Coll Cardiol 2005(18) | Clinical | 44% | 100% | 71% | 78% | 62% |
| Mahrholdt et al., Circulation 2006 (40) | Histology | 95% | 96% | 96% | 99% | 81% |
| Gutberlet et al., Radiology 2008 (34) | Histology | 27% | 80% | 49% | 65% | 44% |
| Yilmaz et al., Heart 2008 (43) | Histology | 35% | 83% | 51% | 81% | 38% |
| Pooled data (n=336) | 59% | 86% | 68% | 89% | 53% | |
Sens: Sensitivity; Spec: Specificity; Acc: Accuracy; PPV: Positive predictive value; NPV: Negative predictive value