Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Dec 24;28(52):14156–14164. doi: 10.1523/JNEUROSCI.4147-08.2008

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2008 Society for Neuroscience 0270-6474/08/2814156-09$15.00/0

PMC Copyright notice

Figure 1. — Microglia have altered morphology and cluster around amyloid plaques in PDAPP^+/−;CX3CR1/GFP^+/− mice. Three-dimensional reconstructed z-series stack images taken of cortical microglia in (A) PDAPP^+/−;CX3CR1/GFP^+/− mice at 3.5 months of age (in the absence of plaques), in (B) 14-month-old PDAPP^+/−;CX3CR1/GFP^+/− mice around amyloid plaques (blue), in (C) 14-month-old PDAPP^+/−;CX3CR1/GFP^+/− mice in areas lacking plaques, and in (D) 5-month-old PDAPP^−/−;CX3CR1/GFP^+/− mice. GFP-labeled microglia are green. Vessels are labeled with Texas Red dextran. Amyloid fluoresces blue after injection of methoxy-XO4. Scale bar, 20 μm.