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Peripheral m3D6 administration results in marked morphological changes in microglia. Three-dimensional reconstructed z-series stack images taken of 22-month-old PDAPP+/−;CX3CR1/GFP+/− mice injected with 500 μg of m3D6 (A–C), an anti-Aβ antibody, or not injected (D–F). GFP-labeled microglia are green. Fibrillar amyloid was labeled with methoxy-XO4 (blue). Scale bar, 20 μm.
