Figure 5.

Iba-1 staining colocalizes with GFP-labeled microglia, and there is increased staining around plaques after m3D6 administration. Brain sections from 18-month-old PDAPP^+/−;CX3CR1/GFP^+/− mice were stained with Iba-1, and images were taken at low power (A–H) and high power (I–P). Iba-1-positive cells are in red (A, E, I, M), GFP labels CX3CR1-positive microglia (B, F, J, N), and methoxy-XO4 labels aggregated amyloid in blue (C, G, K, O). Merged images are also shown (D, G, L, P). Scale bars are 100 and 50 μm, respectively, for low-power and high-power images.