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. 2008 Dec 24;28(52):14156–14164. doi: 10.1523/JNEUROSCI.4147-08.2008

Figure 7.

Figure 7.

Microglial activation after antibody treatment requires recognition of aggregated Aβ and the Fc domain. The number of microglial processes (A) and the number of microglial cells (B) were counted in three-dimensional reconstructed z-series stack images in 18-month-old PDAPP+/−;CX3CR1/GFP+/− mice not injected (untreated) or injected with 500 μg of m3D6, 500 μg of IgG2b, 500 μg of mHJ5.1, and 500 μg of m3D6 Fab fragments. Four mice were studied per treatment group, and 6–10 fields of view were imaged in each animal. Data are presented as the mean ± SEM; *p < 0.001.