Table 2.

Peripheral m3D6 injection increases the number of microglial cells in 22-month-old PDAPP^+/−;CX3CR1^+/− mice

Treatment	All cortical areas	CAA	Plaques	Little/no pathology
m3D6	31.9 ± 1.87	30.2 ± 2.54	36.3 ± 6.42	30.2 ± 3.04
Noninjected	19.3 ± 0.77	19.7 ± 1.09	21.7 ± 1.70	16.9 ± 1.11

The number of microglial cells were counted in three-dimensional reconstructed z-series stack images in 22-month-old PDAPP^+/−;CX3CR1/GFP^+/− mice injected with 500 μg of m3D6 or in untreated mice. All cortical area samples were quantified, and the images were also divided into groups based on the presence of visualized pathology: in the vicinity of CAA, in the vicinity of parenchymal amyloid plaques, and in areas with little to no amyloid pathology. Four mice were studied per treatment group, and 6–10 fields of view were imaged in each animal. Data are presented as mean ± SEM. Peripheral m3D6 injection increases the number of microglial cells in 22-month-old PDAPP^+/−;CX3CR1^+/− mice.