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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Cell Death Differ. 2009 Jan 16;16(5):684–696. doi: 10.1038/cdd.2008.195

Figure 5. Loss of Noxa did not further augment the elevated leukocytes in pre-malignant Eμ-myc mice lacking one or both puma alleles.

Figure 5

(a) Bone marrow cellularity (both femora) and cell subset composition of pre-neoplastic 5- to 6-week-old mice of the indicated genotypes. Values represent means ± S.E.M. from 5 to 8 mice of each genotype. All differences between non-transgenic and Eμ-myc mice were significant (P<0.05) for total B cells and pre-B cells; as were comparisons of total B cells and pro-B cells for wt versus Eμ-myc/noxa−/− mice and for mature B cells for wt versus Eμ-myc and for wt versus Eμ-myc/noxa−/−puma+/− mice. For comparisons of Eμ-myc transgenic mice of the different noxa and puma genotypes, statistically significant differences are indicated. (b) White blood cell counts (means ± S.E.M.) of pre-neoplastic 4 week-old mice of the indicated genotypes. Numbers of Eμ-myc, Eμ-myc/noxa−/−, Eμ-myc/noxa−/−puma+/− mice and Eμ-myc/noxa−/−puma−/− mice were 31, 31, 32 and 14, respectively. (c) Spleen weights of pre-neoplastic 5- to 6-week-old mice. For B and C, differences between transgenic genotypes were significant as indicated. Values represent means ± S.E.M. from 5 to 8 mice of each genotype. *P<0.05, **P<0.01, ***P<0.005