TABLE III.
Literature Review of Vestibular–Related Findings in Selected Cohort of 10q Deletion Patients
| Patient information |
Deletion characteristics |
Symptomatology |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Refs. | Patient # | Sex | 10q deletion | cent-q26.12 | 26.12−26.13 | 26.13-ter | Hearing loss | Vestib. disfxn | Strab ismus | Speech/language |
| This study | 1 | F | 26.2ter | D | D | HZ | – | MU | + | SD |
| This study | 2 | F | 26.2ter | D | D | HZ | – | DW | + | SD |
| This study | 3 | M | 26.12ter | D | HZ | HZ | SNHL | DW, WBG | + | SD |
| This study | 4 | M | 25.3−26.13 | HZ | HZ | D | SNHL | DW, WBG | − | SD |
| McCandless et al. [2000] | 1 | M | 25.1−25.3 | HZ | D | D | SNHL | NT | − | NS |
| Irving et al. [2003] | 13 | F | 25.2−26.1 | HZ | U | D | – | − | SD | |
| Irving et al. [2003] | 12 | F | 25.2−26.1 | HZ | U | D | SNHL | PC | + | SD |
| Petersen et al. [1998] | 1 | F | 25.3-ter | HZ | HZ | HZ | SNHL | WBG | + | SD |
| Irving et al. [2003] | 15 | F | 26.1ter | U | HZ | HZ | – | NT | − | |
| Irving et al. [2003] | 14 | M | 26.13−26.3 | D | HZ | HZ | CHL | DW | + | SD |
| Wulfsberg et al. [1989] | 1 | F | 26.1 | D | U | HZ | SNHL | NT | + | |
| Teyssier et al. [1992] | 1 | M | 26 | U | HZ | HZ | SNHL | NT | − | |
| Tanabe et al. [1999] | 1 | M | 26.11 | D | HZ | HZ | – | NT | + | SD |
| Leonard et al. [1999] | 1 | M | 26.1-ter | D | U | HZ | – | WBG | + | SD |
| Irving et al. [2003] | 11 | F | 26.1ter | U | HZ | HZ | – | DW | − | SD |
| Joshi et al. [2006] | 1 | M | 26.13 | D | U | HZ | CHL | + | ||
| Courtens et al. [2006] | 1 | F | 26.2 | D | D | U | – | DW | + | SD |
| Irving et al. [2003] | 9 | F | 26.2ter | D | D | HZ | – | PB | + | Normal |
| Irving et al. [2003] | 8 | F | 26.2ter | D | D | HZ | – | DW | − | SD |
| Irving et al. [2003] | 7 | F | 26.2ter | D | D | HZ | – | − | Normal | |
| Irving et al. [2003] | 6 | F | 26.2ter | D | D | HZ | – | + | SD | |
| Irving et al. [2003] | 5 | F | 26.2ter | D | D | HZ | – | − | SD | |
| Irving et al. [2003] | 4 | F | 26.2ter | D | D | HZ | – | DW | − | SD |
| Irving et al. [2003] | 3 | F | 26.2ter | D | D | HZ | – | DW | + | Normal |
| Irving et al. [2003] | 2 | F | 26.2ter | D | D | HZ | – | DW | − | Normal |
| Irving et al. [2003] | 1 | F | 26.2ter | D | D | HZ | – | + | Normal | |
The patient information refers to the first author of the relevant publication and the patient number therein. F, female; M, male; HZ, heterozygous; U, uncertain; D, diploid; SNHL, sensorineural hearing loss; NT, not tested; MU, mildly unsteady; DW, delayed walking; PC, poor coordination; PB, poor balance; WBG, wide-based gait; SD, speech delay; AS, absent speech; CHL, conductive hearing loss; +, symptom present; -, symptom absent.