Table 2.

Specific features of protein content^* in telomerized cells

Structural proteins		β5-tubulin	-

		Lamin A/C	-

		Tropomyosin 3	-

Maintenance of cell structure	Proteins of focal adhesion regions	Lasp-1	-

		ZYX	+

		Light alkaline chain of myosin, isoform 1	+

	Destabilization of microtubules	Statmin 1	+

	Growth of actin filaments	Protein capping F-actin, subunit β	+

Protein metabolism	Proteins-chaperones	Heat shock protein 4, 70 kDa	+

		Heat shock protein 9B, 70 kDa	+

		T-complex 1	+

		AHSA1	+

		HSPA8	+

		Heat shock protein 1, 27 kDa	-

	Increased presentation of MHC-1	Proteasome activator PA28, β-chain	+

Proliferation	Growth factor	Transferrin	+

	Extracellular protease inhibitor	α2-Macroglobulin	-

	Cofactor of DNA-polymerase	Proliferating cell nuclear antigen (PCNA)	+

Protection against reactive oxygen forms		Superoxide dismutase 1 (SOD1)	-

		Superoxide dismutase 2 (SOD2)	-

	Extracellular protections	Thioredoxin	+

		Peroxyredoxin 6	+

		Protein resembling thioredoxin (TXNL1)	+

	Production of NADP—key donor of electrons	Glucose-6-phosphate dehydrogenase	+

	Maintenance of glutathione in reduced state	Transaldolase	+