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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Bioconjug Chem. 2006 Nov–Dec;17(6):1545–1550. doi: 10.1021/bc060154p

Scheme 1. Solid-phase Synthesis of Compounds 9–11 Containing Linked NDP-α-MSH Ligands and Control Compounds 12–14.

Scheme 1

Reagents and conditions: (a) piperidine. (b) Fmoc/tBu solid-phase synthesis (Refs 18 and 19). (c) N-protected linker (5, 6, or 7), HOCt-DIC, DMF. (d) THF/MeOH/N2H4 (70/15/15). (e) pyridine/Ac2O (50/50). (f) CF3CO2H/HSCH2CH2SH/PhSMe/H2O (91/3/3/3).