Table 5.
IC50 and sensitization ratio of doxorubicin and combinations with Rosco towards human colorectal cancer cell lines
| Treatment with doxorubicin and its combinations with Rosco |
IC50 (mol/L) |
Sensitization ratio1 |
||||
| SW48 | SW1116 | SW837 | SW48 | SW1116 | SW837 | |
| Dox. | 5.4 × 10-8 | 6 × 10-7 | 4.1 × 10-7 | - | - | - |
| Dox. + 5 μg/mL Rosco | 5.8 × 10-11 | 2 × 10-7 | 4.1 × 10-8 | 9.3 × 102 | 3 | 10 |
| Dox. + 10 μg/mL Rosco | 5.8 × 10-11 | 4.5 × 10-9 | 8.2 × 10-10 | 9.3 × 102 | 1.3 × 102 | 5.0 × 102 |
1
Sensitization ratio = IC50 (Dox.)/IC50 (Dox. + Rosco).