Table 7.
IC50 and sensitization ratio of vinblastine and its combinations with Rosco towards human colorectal cancer cell lines
| Treatment with vinblastine and combinations with Rosco |
IC50 (mol/L) |
Sensitization ratio1 |
||||
| SW48 | SW1116 | SW837 | SW48 | SW1116 | SW837 | |
| Vinb. | 1 × 10-8 | 6.3 × 10-7 | 4.2 × 10-7 | - | - | - |
| Vinb. + 5 μg/mL Rosco | 5.4 × 10-11 | 7.5 × 10-8 | 5.0 × 10-8 | 1.9 × 102 | 8.4 | 8.4 |
| Vinb. + 10 μg/mL Rosco | 5.4 × 10-11 | 7.9 × 10-10 | 4.6 × 10-10 | 1.9 × 102 | 8.0 × 102 | 9.1 × 102 |
1
Sensitization ratio = IC50 (Vinb.)/IC50 (Vinb. + Rosco).