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. Author manuscript; available in PMC: 2010 May 26.
Published in final edited form as: Circulation. 2009 May 11;119(20):2686–2692. doi: 10.1161/CIRCULATIONAHA.108.790485

Figure 2. Neointimal formation in Notch mutant mice following vascular injury.

Figure 2

Carotid arteries were collected 28 days after the procedure. HE staining was performed on sections from WT, smCre-Tg, N1+/-, N3-/- and smN1+/- mice. Arrows indicate internal elastic lamina.

A. Representative sections are shown. Scale bar, 100 μm.

B. Quantitative morphometric analysis of intimal area in WT, smCre-Tg, N1+/-, N3-/- and smN1+/- mice. n=10 in each group, *; P<0.01, vs. WT; †; P<0.01, vs. smCre-Tg

C. Attenuated intima/media area ratio in Notch1 mutant, but not N3-/- mice compared with control mice. n=10 in each group, *; P<0.01, vs. WT; †; P<0.01, vs. smCre-Tg