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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: ACS Chem Biol. 2009 May 15;4(5):335–344. doi: 10.1021/cb900028j

Figure 1. Natural and designer transcriptional activation domains (TADs).

Figure 1

a) Key sequences from amphipathic TADs that interact with the coactivator CBP. b) Isoxazolidine TADs (iTADs) that were designed to generically mimic their natural counterparts and up-regulate transcription when localized to a specific promoter (when R = DBD).(42-45)