Represents Ct values for MMP-2 (A), MMP-9 (B), TIMP-3 (C) and TIMP-4(D) in WT, CBS-/+, CBS-/+ / GABAA -/- and GABAA -/-. Lesser the value of Ct represents more the quantity of gene. One Ct difference signifies two fold increases in gene quantity. There is significant increase in MMP-2, MMP-9 activity or decrease in Ct values. There is significant increase in TIMP-4 and decrease in TIMP-3 expression or decrease in Ct values for TIMP-4 and increase for TIMP-3. The bar graph represents mean ± SEM in three experiments. *p<0.05 compared to WT.