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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Physiol Rev. 2008 Jul;88(3):887–918. doi: 10.1152/physrev.00033.2007

Figure 5. Proposed model for the involvement of LRP1 in remnant metabolism in the liver.

Figure 5

The model is adapted from (145,148). Remnant lipoprotein particles entering the space of Disse in the liver are first thought to be sequestered by association with heparan sulfate proteoglycans (HSPG). Here they are remodeled by the action of lipoprotein lipase (LPL) and hepatic lipase (HL). Internalization by the hepatocytes is mediated directly by HSPG, the LDL receptor, or HSPG/LRP1 complexes.