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. Author manuscript; available in PMC: 2010 May 27.
Published in final edited form as: J Med Chem. 2009 May 28;52(10):3191–3204. doi: 10.1021/jm800861c

Figure 1.

Figure 1

Structures of methisazone, 9, and the seven isatin-β-thiosemicarbazones (1-7) identified in a bioinformatics screen as having activity that is potentiated, rather than inhibited by expression of the multidrug transporter P-gp. 1 is being treated as a lead compound to understand the mechanism of action of the compounds. An overlay of the seven NSC compounds identified in the bioinformatics screen demonstrates the common structural features associated with them.