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. 2009 Sep 2;29(35):10979–10988. doi: 10.1523/JNEUROSCI.1531-09.2009

Figure 3.

Figure 3.

Effects of the Ih inhibitor ZD7288 on dendritic HCN1−/− and wild-type excitability. A, B, Example recordings obtained from HCN1−/− or WT (control) dendrites of EC layer III neurons in the absence and presence ZD7288 (15 μm). A series of 400 ms hyperpolarizing and depolarizing steps in 50 pA increments were applied to produce the traces. In all cases, the cells were held at the normal RMP (NRMP). Application of ZD7288 hyperpolarized WT dendrites, and, therefore, traces were obtained at the hyperpolarized RMP (HRMP) and, for comparison purposes, at the original RMP (ORMP). Calibration: 20 mV, 250 ms. The mean number of action potentials generated in response to depolarizing current pulses before (control) and after ZD7288 at the hyperpolarized RMP or original RMP are shown on the far right of each panel. C, Average changes in RMP produced by application of ZD7288 (ZD) on WT and HCN1−/− soma. *p < 0.05. Con, Control.