Table 2.
Incidence of neural neoplasias and advanced neuroblastoma in Hag heterozygotes, homozygotes and wild type siblings over time
| Allele | Age (weeks) | Wild types | Heterozygotes | Homozygotes | |
|---|---|---|---|---|---|
| hiD4000 | 12 | Small neoplasias | 0/17 | 28/30 (93%) | 17/20 (85%) |
| Advanced tumors | 0/17 | 0/30 | 0/20 | ||
| Dead* | 0/17 | 0/30 | 0/20 | ||
| 24 | Small neoplasias | 0/10 | 20/28 (71%) | 7/9 (78%) | |
| Advanced tumors | 0/10 | 1/28 (4%) | 0/9 | ||
| Dead* | 0/10 | 0/28 | 4/13 (31%) | ||
| 31 | Small neoplasias | 0/16 | 18/28 (64%) | 0/2 | |
| Advanced tumors | 0/16 | 0/28 | 1/2 (50%) | ||
| Dead* | 0/16 | 0/28 | 6/8 (75%) | ||
| 39 | Small neoplasias | N.D. | 6/14 (43%) | 3/10 (30%) | |
| Advanced tumors | N.D. | 2/14 (14%) | 4/10 (40%) | ||
| Dead* | N.D. | 0/14 | 7/17 (41%) | ||
| hiD1 | 17 | Small neoplasias | 0/10 | 22/26 (85%) | 9/11 (82%) |
| Advanced tumors | 0/10 | 0/26 | 0/11 | ||
| Dead* | N.D. | N.D. | N.D. | ||
| 24 | Small neoplasias | 0/21 | 37/52 (71%) | 3/13 (38%) | |
| Advanced tumors | 0/21 | 6/52 (11%) | 4/13 (31%) | ||
| Dead* | N.D. | N.D. | N.D. | ||
| 34 | Small neoplasias | N.D. | 3/10 (30%) | 3/7 (43%) | |
| Advanced tumors | N.D. | 3/10 (30%) | 2/7 (29%) | ||
| Dead* | N.D. | 0/10 | 2/7 (29%) | ||
| hiD2058 | 17 | Small neoplasias | 0/16 | 14/17 (82%) | 9/11 (82%) |
| Advanced tumors | 0/16 | 0/17 | 0/11 | ||
| Dead* | N.D. | N.D. | N.D. | ||
| 24 | Small neoplasias | 0/15 | 29/37 (78%) | 8/11 (73%) | |
| Advanced tumors | 0/15 | 0/37 | 2/11 (18%) | ||
| Dead* | N.D. | N.D. | N.D. | ||
| 34 | Small neoplasias | 0/6 | 5/11 (45%) | 4/14 (29%) | |
| Advanced tumors | 0/6 | 4/11 (36%) | 6/14 (43%) | ||
| Dead* | 0/6 | 0/11 | 4/18 (22%) | ||
| hiD2 | 24 | Small neoplasias | 0/12 | 33/38 (87%) | 11/17 (64%) |
| Advanced tumors | 0/12 | 0/38 | 1/17 (6%) | ||
| Dead* | N.D. | N.D. | N.D. |
*
these fish died from wasting, presumably subsequent to severe esophageal/gut inflammation, not from tumors. N.D., not determined.