Table 5. Adjudication Disagreements.

Table 5 shows the reasons for adjudication disagreement at the primary (Level 2b) adjudication level. This table includes the total number of disagreements at that level (attributed chronologic numbers instead of actual spoke randomization numbers), whether they were telephone or telemedicine, reason for disagreement in each case, presence of subsequent ICH, and 90 day outcomes.

Patient #	Group	rt-PA	Reason for Disagreement	ICH	90 day BI, mRS
1	Telephone	N	Would have treated mild arm weakness & NIHSS=3.	N	BI=100, mRS=0
2	Telephone	N	Patient didn’t awake with deficit. Deficit noted at bathroom. Likely in window. Would have treated.	N	Death
3	Telephone	N	Would have treated ‘mild’ deficit.	N	BI=100, mRS=0
4	Telephone	Y	Decision made too quickly. Blood pressure > 185. Would have rechecked, as still within 3 hour window.	N	BI=75, mRS=4
5	Telephone	N	Would have treated significant symptoms	N	BI=100, mRS=0
6	Telephone	N	Not a TIA. Would have treated the aphasia.	N	BI=85, mRS=3
7	Telephone	N	Would have treated mild symptoms.	N	Withdrew Consent
8	Telephone	N	Would have treated patient with early hypodensity (likely early ischemic changes only).	N	BI=80, mRS=3
9	Telephone	Y	Likely greater than 3 hrs. Would not have treated.	N	BI=100, mRS=0
10	Telephone	N	Would have treated aphasia (in a teacher).	N	BI=100, mRS=0
11	Telephone	Y	“Open wound” and would have waited for glucose.	N	BI=10, mRS=5
12	Telephone	N	Would have waited longer for fluctuating symptoms.	N	Lost to Follow-up
13	Telephone	Y	Greater than 3 hrs. Would not have treated.	N	BI=100, mRS=2
14	Telephone	N	No CT scan done, would have treated mild deficit.	N	BI=100, mRS=0
15	Telephone	N	Would have treated “improving” symptoms.	N	BI=100, mRS=1
16	Telephone	N	Would have treated aphasia and weakness.	N	BI=100, mRS=1
17	Telephone	N	No attempt to lower blood pressure, & patient had a measurable deficit.	N	BI=100, mRS=0
18	Telephone	Y	Would not have treated mild isolated sensory deficit.	N	BI=55, mRS=4
19	Telemedicine	Y	Possibility of aortic dissection not fully excluded.	N	BI=100, mRS=0
20	Telemedicine	Y	Onset time questionable for posterior circulation stroke (patient awoke with vertigo).	N	BI=100, mRS=2
21	Telephone	Y	Would not have treated due to BP exclusion.	N	BI=55, mRS=4
22	Telephone	N	Would have treated aphasia, slurred speech and sensory loss.	N	BI=100, mRS=1