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Ionomycin-induced eNOS-dependent relaxation in endothelium-intact mouse aortic rings from wildtype (Gla +/0) or Gla knockout (Gla -/0) mice pre-contracted with an EC80 concentration of PE a) alone without any pharmacological intervention or b) in the presence of 10-4 mol/L Nω-nitro-l-arginine (LNNA). Data are expressed as a percentage of the contraction elicited by PE EC80. p>0.05 by two-way ANOVA in all figures.
