Table 2.
Potency of agonists in vascular reactivity of thoracic aortas with endothelium intact, in the presence of 3 × 10-4 mol/L Nω-nitro-l-arginine (LNNA) from wildtype (Gla +/0) or Gla knockout (Gla -/0) mice. Data are reported as mean ± SEM for the number of animals in parentheses. The EC50 values are expressed as the −log EC50 for each agonist. * = p<0.05 compared to Gla +/0 by the Student t test.
| Agonist | -log EC50 [M] | |
|---|---|---|
| Gla +/0 (+LNNA) | Gla -/0 (+LNNA) | |
| PE | 7.37 ± 0.04 (12) | 7.17 ± 0.05 (13) * |
| 5HT | 7.19 ± 0.02 (6) | 6.96 ± 0.04 (6) * |
| U46619 | 9.08 ± 0.03 (6) | 8.95 ± 0.03 (6) * |
| Ach | 6.57 ± 0.20 (7) | 6.76 ± 0.31 (7) |
| Ionomycin | 8.01 ± 0.31 (5) | 7.77 ± 0.21 (6) |
| SNP | 9.07 ± 0.13 (5) | 9.11 ± 0.02 (5) * |