. Author manuscript; available in PMC: 2009 Sep 15.

Published in final edited form as: Clin Exp Pharmacol Physiol. 2008 Jun 18;35(10):1156–1163. doi: 10.1111/j.1440-1681.2008.04984.x

Table 2.

Potency of agonists in vascular reactivity of thoracic aortas with endothelium intact, in the presence of 3 × 10^-4 mol/L N_ω-nitro-_l-arginine (LNNA) from wildtype (Gla +/0) or Gla knockout (Gla -/0) mice. Data are reported as mean ± SEM for the number of animals in parentheses. The EC₅₀ values are expressed as the −log EC₅₀ for each agonist. * = p<0.05 compared to Gla +/0 by the Student t test.

Agonist	-log EC₅₀ [M]

	Gla +/0 (+LNNA)	Gla -/0 (+LNNA)
PE	7.37 ± 0.04 (12)	7.17 ± 0.05 (13) *
5HT	7.19 ± 0.02 (6)	6.96 ± 0.04 (6) *
U46619	9.08 ± 0.03 (6)	8.95 ± 0.03 (6) *
Ach	6.57 ± 0.20 (7)	6.76 ± 0.31 (7)
Ionomycin	8.01 ± 0.31 (5)	7.77 ± 0.21 (6)
SNP	9.07 ± 0.13 (5)	9.11 ± 0.02 (5) *