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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Appl Opt. 2008 Nov 1;47(31):5944–5952. doi: 10.1364/ao.47.005944

Fig. 4.

Fig. 4

IRDye800CW allows measurement of biodistribution and migration of CTLs. (Media 2) (Media 3) (a) Athymic nude mice were injected s.c. with LCL cells followed by injection of either IRDye800CW dye alone (left panel) or EBV-specific CTLs labeled with IRDye800CW. After 1 h, mice were imaged for NIR signal. Mice injected with IRDye800CW alone show nonspecific NIR accumulation in the liver, whereas mice injected with CTL + IRDye800CW show that CTLs accumulate in the lungs shortly after i.v. injection. (b) After 48 h, mice with injected with IRDye800CW-labeled CTLs were examined for NIR signal. NIR signal accumulation was observed in the tumor site (indicated by an arrow) and nonspecific signal in the kidneys, demonstrating that IRDye800CW labeling can be used to detect migration of CTLs to distant tumor sites.