Skip to main content
. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Neurocrit Care. 2008 Oct 16;10(1):93–102. doi: 10.1007/s12028-008-9153-0

Figure 6.

Figure 6

Phenylephrine (PE) concentration-response curves in femoral artery. A, Cumulative concentration-response curve of basilar artery constriction normalized to 100 mM KCl induced-contraction, control arterial segments are compared to segments incubated with increasing concentration of dantrolene from 10–100μM (*EC50 of 100μM compared to control). B, The effect of dantrolene (10μM) plus nimodipine (30nM) (*EC50 and Emax of nimodipine compared to control; *Emax of dantrolene+nimodipine compared to nimodipine or dantrolene alone). C, The effect of dantrolene (30μM) plus nimodipine (30nM) (*Emax of dantrolene+nimodipine compared to nimodipine or dantrolene alone). D, The effect of dantrolene (100μM) plus nimodipine (30nM) (*Emax of dantrolene+nimodipine compared to nimodipine or dantrolene alone). The effective concentration of PE that gave 50% contraction (EC50) for each treatment is listed below the respective graph.