Table 2.

P53 is pro-oxidant in the central nervous system

	Tissues
	Liver	Lung	Cortex
MDA adducta	1.58 ± 0.13*	1.91 ± 0.11*	0.58 ± 0.04*
Gene expression levelsb
xCT	0.24 ± 0.01*	0.35 ± 0.04*	1.65 ± 0.11*
GST	1.70 ± 0.19*	0.78 ± 0.09*	1.78 ± 0.03*
NQO	0.94 ± 0.03	0.43 ± 0.08*	1.37 ± 0.07*
Sesn1	0.85 ± 0.03*	0.31 ± 0.06*	1.53 ± 0.17*
Sesn2	0.24 ± 0.01*	0.27 ± 0.04*	1.48 ± 0.04*
Sod1	0.90 ± 0.03	0.87 ± 0.03*	1.42 ± 0.04*
Sod2	0.78 ± 0.03*	0.61 ± 0.03*	1.00 ± 0.09

^aLipid peroxidation was measured in p53^−/− liver, lung, and brain homogenates as concentration of MDA. Data were normalized to sample protein contents and are represented as fold change relative to WT samples set at 1. Results are mean ± SD (n = 3–5; *p < 0.05).

^bReal-time PCR analysis of antioxidant gene expression levels in p53^−/− liver, lung, and brain. Data are represented as fold change relative to WT samples set at 1. Results are mean ± SD (n = 3–4; *p < 0.05).