Table 2.
Clinical Characteristics of Genotype-Specific Subsets of Patients With Non–Small-Cell Lung Cancer
| Characteristic | Genotype |
P |
||||||
|---|---|---|---|---|---|---|---|---|
|
ALK (n = 19) |
EGFR (n = 31) |
WT/WT (n = 91) |
||||||
| No. | % | No. | % | No. | % | ALK v EGFR | ALK v WT/WT | |
| Age, years | ||||||||
| Median | 52 | 66 | 64 | < .001 | .005 | |||
| Range | 29-76 | 36-90 | 29-87 | |||||
| Sex | ||||||||
| Male | 11 | 58 | 8 | 26 | 29 | 32 | .036 | .039 |
| Female | 8 | 42 | 23 | 74 | 62 | 68 | ||
| Smoking history | ||||||||
| Never smoker | 14 | 74 | 21 | 68 | 24 | 26 | .366 | < .001 |
| Light smoker | 5 | 26 | 6 | 19 | 15 | 16 | ||
| Smoker | 0 | 0 | 4 | 13 | 52 | 57 | ||
| Ethnicity | ||||||||
| Asian | 0 | 0 | 2 | 6 | 7 | 8 | .519 | .602 |
| Non-Asian | 19 | 100 | 29 | 94 | 84 | 92 | ||
| Pathology | ||||||||
| Adeno | 16 | 84 | 24 | 77 | 49 | 54 | .380* | .686* |
| BAC† | 2 | 11 | 7 | 23 | 32 | 35 | ||
| Adenosquamous | 1 | 5 | 0 | 0 | 3 | 3 | ||
| Squamous | 0 | 0 | 0 | 0 | 2 | 2 | ||
| Large cell/NOS | 0 | 0 | 0 | 0 | 5 | 6 | ||
| Stage | ||||||||
| IA | 2 | 11 | 2 | 6 | 10 | 11 | ||
| IB | 0 | 0 | 1 | 3 | 10 | 11 | ||
| IIA | 0 | 0 | 0 | 0 | 1 | 1 | ||
| IIB | 0 | 0 | 0 | 0 | 0 | 0 | ||
| IIIA | 0 | 0 | 2 | 6 | 3 | 3 | ||
| IIIB | 0 | 0 | 0 | 0 | 4 | 4 | ||
| IV | 17 | 89 | 26 | 84 | 53 | 58 | .695‡ | .051‡ |
| Multifocal BAC | 0 | 0 | 0 | 0 | 10 | 11 | ||
Abbreviations: WT, wild type; adeno, adenocarcinoma; BAC, bronchioloalveolar carcinoma; NOS, not otherwise specified.
*
Adeno and BAC v all others.
†
Adeno with any element of BAC is listed as BAC.
‡
Stages I to III v IV.