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. 2009 Sep 18;4(9):e6525. doi: 10.1371/journal.pone.0006525

Figure 5. Effect of VEGFR1-blockade on BMDC infiltration in lungs prior to macroscopic metastasis formation.

Figure 5

Treatment of tumor bearing mice with MF1 antibody did not change the infiltration with BMDCs in lungs at the time of primary tumor resection (day 0) or 10 days after primary tumor removal. Representative images of lung tissue from non-tumor bearing C57BL (A) and BMT-Actb-GFP/C57BL (B) mice and from LLC1-tumor bearing mice at the time of primary tumor resection (day 0) after treatment with IgG (C) or MF1 (D). The number of BMDCs was calculated as the ratio of green fluorescence protein (GFP)-surface area to DAPI-surface area (E). DAPI was used to stain the nuclei of all cells (n = 6–8 mice per group). All images are 512 µm across.