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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: J Cereb Blood Flow Metab. 2009 May 6;29(7):1229–1239. doi: 10.1038/jcbfm.2009.48

Figure 1. Hypothesized Method of Feridex Accumulation with 7-day Preloading.

Figure 1

Feridex has a blood half-life of 5–6 hours, the majority of which is cleared by the reticuloendothelial system (RES). The remainder accumulates in the bone marrow previous to ischemic insult. Following ischemia-reperfusion (I–R), these iron-laden macrophages are recruited to the stroke region. Using non-invasive MRI, their involvement in the acute and subacute/chronic phase of the inflammatory cascade may be monitored.